Neurological Surgery

Surgeons in the Department of Neurosurgery treat adult and pediatric patients with disorders of the nervous system, brain, meninges, skull, and blood supply, the extracranial carotid and vertebral arteries; brain tumors, disorders of the pituitary gland, disorders of the spinal cord, meninges, and vertebral column, including those which may require treatment by spinal fusion or instrumentation; and disorders of the cranial, spinal and peripheral nerves.

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Home > Physicians Directory > Neurological Surgery

David D. Limbrick, MD, PhD

Specialty Areas
Pediatric Neurosurgery
Pediatric Epilepsy
Brain Tumors - Pediatric

Areas of Clinical Interest
Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine.

Areas of Research Interest
Cerebrospinal fluid physiology and neonatal hydrocephalus.

Major or Recent Publications/Awards

Select Publications

Limbrick, D.D.J., Behdad, A., Derdeyn, C.P., Zipfel, G.J., and Santiago, P. Traumatic avulsion of the ophthalmic artery mimics aneurysmal subarachnoid hemorrhage and clinical course. Journal of Neurosurgery In press.

Limbrick, D.D.J., Narayan, P., Powers, A.K., Ojemann, J.G., Park, T.S., Bertrand, M., and Smyth, M.D. Hemispherotomy: Efficacy and analysis of seizure recurrence. J Neurosurg Peds, In press.

Johnston, J.M., Limbrick, D.D.J., Ray, W.Z. and Park, T.S. Isolated cerebellar Rosai-Dorfman granuloma mimicking Lhermitte-DuClos: Case presentation and review of the literature. J Neurosurg Peds In press.

Lipira, A., Limbrick, D., Haughey, B., Custer, P., and Chicoine, M. Titanium mesh reconstruction to maintain scalp contour after temporalis musculo-fascial flap reconstruction of middle fossa floor: A technical note and report of two cases. Skull Base In press.

Behdad, A.,* Limbrick, D.D.J.,* and Smyth, M.D. Epilepsy surgery in children with seizures arising from the Rolandic cortex. Epilepsia In press.

Miller, J.H., Limbrick, D.D.J., Callen, M., and Smyth M.D. Spontaneous resolution of Chiari type I malformation in monozygotic twins. J Neurosurg Peds 2: 317-19, 2008.

Goldhoff, P.*, Warrington, N.*, Limbrick, D.D.J.*, Hope, A., Woerner, B.M., Jackson, E., Perry, A., Piwnica-Worms, D., and Rubin, J.B. Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res 12: 7717-25, 2008.

Kiehl, E., Stojadinovic, S., Malinowski, K.T., Limbrick, D., Jost, S.C., Rubin J.B., Deasy, J.O., Parikh, P.J., Lowe, D.A.,  Hope, A.J. CNS radiotherapy. Medical Physics 2008; 35: 4735-43

Johnston, J.M., Limbrick, D., Wright, N., Park, T.S., and Leonard, J.R. Complications, Fusion Rate and Neurologic Outcome After Surgical Stabilization of Thoracolumbar Fractures in Children and Adolescents. J Neurosurg Peds, Under review.

Limbrick, D.D.J., Behdad, A., Derdeyn, C.P., Zipfel, G.J., and Santiago, P. Traumatic Avulsion of the Opthalmic Artery Mimics Aneurysmal Subarachnoid Hemorrhage and Clinical Course. Neurosurgery, Under review.

Warrington, N.*, Goldhoff, P.*, Limbrick, D.D.J.*, Hope, A., Woerner, B.M., Jackson, E., Rao, M., Perry, A., Piwnica-Worms, D., and Rubin, J.B. Phosphodiesterase Type 4 stimulates intracranial Brain Tumor Growth and constitutes an important target in multi-modal brain tumor therapy. Clinical Cancer Research In press. *These authors contributed equally to this study.

Limbrick, D.D.J., Lusis, E.A., Chicoine, M.R., Simpson, J.R., Rich, K.M., Dacey, R.G., Dowling, J.L., Grubb, R.L., Filiput, E.A., Drzymala, R.E., Mansur, D.B., and Malyapa, R.S. Combined surgical resection and stereotactic radiosurgery for treatment of cerebral metastases. Surgical Neurology In press.

Limbrick, D.D.J., Leonard, J.C., Wright, N.M., Leonard, J.R. Cervical Spine Trauma in Children, Including Spinal Cord Injury Without Radiographic Abnormality, in Kim, D., Betz, R., Huhn, S., and Newton, P. (eds) Surgery of the Pediatric Spine. Thieme Medical Publishers, New York, 2008, p.489-500.

Smyth, M.D, Limbrick, D.D.J., Ojemann, J.G., Zempel, J., Robinson, S., O’Brien, D.F., Saneto, R.P., Goyal, M., Appleton R.E., Mangano, F.T., and Park, T.S. Surgical outcomes for temporal lobe epilepsy and hippocampal sclerosis in young children. Journal of Neurosurgery 106:205-10, 2007.

Deshpande, L.S., Limbrick, D.D., Sombati, S., and Delorenzo, R.J. Activation of a novel injury-induced calcium permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. Journal of Pharmacology and Experimental Therapeutics 322:443-52, 2007.

Schalk, G., Kubanek, J., Miller, K.J., Anderson, N.R., Leuthardt, E.C., Ojemann, J.G., Limbrick, D., Moran, D., Gerhardt, L.A., and Wolpaw, J.R. Decoding two-dimensional movement trajectories using electrocorticography signals in humans. Journal of Neural Engineering 4:264-75, 2007.

Limbrick, D.D.J. and Park, T.S. Occult hydrocephalus in children with cerebral palsy. Neurosurgery 58(3):E590, 2006.

Mangano, F.T., Limbrick, D.D.J., Leonard, J.R., Park, T.S., and Smyth, M.D. Simultaneous image-guided and endoscopic navigation (SIGEN) without rigid skull fixation: application in infants: technical case report. Neurosurgery 58: ONS-E377, 2006.

Limbrick, D.D.J., Wright, N.M. Verification of nerve root decompression during minimally-invasive lumbar microdiskectomy: a practical application of surgeon-driven evoked EMG. Minimally Invasive Neurosurgery 48:273-7, 2005.

Limbrick, D.D.J., Sombati, S., and DeLorenzo, R.J. Calcium influx constitutes the ionic basis for glutamate-induced extended neuronal depolarization in hippocampal neurons. Cell Calcium 33:69-81, 2003.

Limbrick, D.D.J., Pal, S., and DeLorenzo, R.J. Hippocampal neurons exhibit both persistent Ca2+ influx and impairment of Ca2+ sequestration/extrusion mechanisms following excitotoxic glutamate exposure. Brain Research 894: 56-67, 2001.

Pal, S., Sun, D., Limbrick, D., Rafiq, A., and DeLorenzo, R.J. Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy. Cell Calcium 30: 285-96, 2001.

Pal, S., Limbrick, D.D.J., Rafiq, A., and DeLorenzo, R.J. Induction of spontaneous recurrent epileptiform discharges causes long-term changes in intracellular calcium homeostatic mechanisms. Cell Calcium 28: 181-93, 2000.

Pal, S., Sombati, S., Limbrick, D.D.J., and DeLorenzo, R.J. In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons. Brain Research 851: 20-31, 1999.

DeLorenzo, R.J. and Limbrick, D.D.J. Effects of glutamate on calcium influx and sequestration/extrusion mechanisms in hippocampal neurons. Advances in Neurology 71: 37-46, 1996.

Limbrick, D.D.J., Churn, S.B., Sombati, S., and DeLorenzo, R.J. Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death. Brain Research 690: 145-56, 1995.

Churn, S.B., Limbrick, D., Sombati, S., and DeLorenzo, R.J. Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. Journal of Neuroscience 15: 3200-14, 1995.

David D. Limbrick, MD, PhD