John J. Lehman, Jr., MD
Current Position
Instructor, Medicine
Division of Cardiovascular Diseases
Specialty Areas
Cardiovascular Disease
Coronary Artery Disease
Heart Disease
Cardiology
Mailing Address
|
Washington University School of Medicine
Department of Internal Medicine
660 So. Euclid Avenue, Campus Box 8086
St. Louis,
MO
63110
|
Academic Office
|
Center for Cardiovascular Research
Washington University School of Medicine
660 South Euclid Avenue, Box 8086
St. Louis,
MO
63110
(314)362-8908
|
Areas of Clinical Interest
In-Patient care and testing only. Heart disease, heart conditions, coronary artery disease, dilated cardiomyopathy, ventricular infarction, cardiac hypertrophy, cardiac aging, cardiac metabolism, cardiac energetics, cardiac mitochondrial function.
Board Certification
Internal Medicine
--
Certified
This physician is not able to accept new patients at this time.
Medical Education
A.B.: Biochemistry and Molecular Biology, Washington University, St. Louis, Missouri, 1991
Medical Degree: Washington University School of Medicine, St. Louis, Missouri, 1995
Residency: Internal Medicine, Barnes-Jewish Hospital at Washington University School of Medicine, St. Louis, Missouri, 1998
Research Fellowship: Cardiology, Washington University School of Medicine, St. Louis, Missouri, 2001
Clinical Fellowship: Cardiology, Washington University School of Medicine, St. Louis, Missouri, 2003
Hospital Affiliations
Barnes-Jewish Hospital
Major or Recent Publications/Awards
Honors and Awards
Burton E. Sobel Award for Excellence in Cardiovascular Research, 2003
Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators, Finalist (2nd Place), American Heart Association, 2000
Fifth Annual AstraZeneca Cardiovascular Young Investigator's Forum 2nd Place Award in Fellows Basic Science Research Competition, 1999
Publications
Russell LK, Lehman JJ, Mansfield CM, Valencik ML, McDonald JA, Kelly DP. Development of a Transgenic System for Cardiac-Specific Induction of Mitochondrial Biogenesis. In preparation
Finck BN, Lehman JJ, Barger PM, Kelly DP. Regulatory networks controlling mitochondrial energy production in the developing, hypertrophied, and diabetic heart" Cold Spring Harbor Symposia on Quantitative Biology 2002; Vol LXVII:371-382
Lehman JJ, Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Failure Reviews 2002; 7:175-185
Lehman JJ, Kelly DP. Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clinical and Experimental Pharmacology and Physiology 2002; 29:339-345
Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD, Kelly DP. The cardiac phenotype induced by PPARĄ overexpression mimics that caused by diabetes mellitus. The Journal of Clinical Investigation 2002; 109:121-130
Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM. Restoration of Insulin-Sensitive Glucose Transporter (GLUT4) Gene expression in muscle cells by the transcriptional coactivator PGC-1. Proceedings of the National Academy of Sciences USA 2001; 98:3820-3825
Lehman JJ, Barger PM, Saffitz JE, Kovacs A, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. The Journal of Clinical Investigation 2000; 106:847-856
Lehman JJ, Brown K, Ramanadham S, Turk J, Gross RW. Arachidonic acid release from aortic smooth muscle cells induced by [Arg8]vasopressin is largely mediated by calcium-independent
phospholipase A2. The Journal of Biological Chemistry 1993; 268:20713-20716